New BINOL Schiff Base as a Tridentate Ligand for Catalytic Asymmetric Addition of Diethylzinc to Aldehydes in the Presence of Titanium Tetraisopropoxide

Bing      Liu; Cao      Fang; Zhi-Bing      Dong; Jin-Shan      Li

doi:10.2174/157017807780737327

Abstract

We have developed three new chiral 3-substituted BINOL Schiff base ligands for the asymmetric diethylzinc addition to aldehydes in the presence of titanium tetraisopropoxide. The reaction provided optically active second alcohols in high yield and moderate enantioselectivity (up to 67% ee).

Keywords: BINOL, Schiff base, diethylzinc, asymmetric addition, titanium

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Letters in Organic Chemistry

Title: New BINOL Schiff Base as a Tridentate Ligand for Catalytic Asymmetric Addition of Diethylzinc to Aldehydes in the Presence of Titanium Tetraisopropoxide

Volume: 4 Issue: 3

Author(s): Bing Liu, Cao Fang, Zhi-Bing Dong and Jin-Shan Li

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Keywords: BINOL, Schiff base, diethylzinc, asymmetric addition, titanium

Abstract: We have developed three new chiral 3-substituted BINOL Schiff base ligands for the asymmetric diethylzinc addition to aldehydes in the presence of titanium tetraisopropoxide. The reaction provided optically active second alcohols in high yield and moderate enantioselectivity (up to 67% ee).

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Liu Bing, Fang Cao, Dong Zhi-Bing and Li Jin-Shan, New BINOL Schiff Base as a Tridentate Ligand for Catalytic Asymmetric Addition of Diethylzinc to Aldehydes in the Presence of Titanium Tetraisopropoxide, Letters in Organic Chemistry 2007; 4 (3) . https://dx.doi.org/10.2174/157017807780737327