Rational Design of Vector and Antibiotic Peptides Using Solid-State NMR

A.   J.   Mason; B.      Bechinger; A.      Kichler

doi:10.2174/138955707780619563

Abstract

The application of 2H solid-state NMR in determining structure activity relationships and mechanism of action of membrane active peptides is discussed. The enhancement of the disruption of anionic lipids in the membrane by new lead compounds is shown to be a key determinant of both DNA vector and antimicrobial activity.

Keywords: Solid-state NMR, gene transfer, antibiotic peptides, histidine, LAH4, pleurocidin

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Mini-Reviews in Medicinal Chemistry

Title: Rational Design of Vector and Antibiotic Peptides Using Solid-State NMR

Volume: 7 Issue: 5

Author(s): A. J. Mason, B. Bechinger and A. Kichler

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Keywords: Solid-state NMR, gene transfer, antibiotic peptides, histidine, LAH4, pleurocidin

Abstract: The application of 2H solid-state NMR in determining structure activity relationships and mechanism of action of membrane active peptides is discussed. The enhancement of the disruption of anionic lipids in the membrane by new lead compounds is shown to be a key determinant of both DNA vector and antimicrobial activity.

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Mason J. A., Bechinger B. and Kichler A., Rational Design of Vector and Antibiotic Peptides Using Solid-State NMR, Mini-Reviews in Medicinal Chemistry 2007; 7 (5) . https://dx.doi.org/10.2174/138955707780619563