Reduced-Intensity Stem Cell Transplantation for Hematological Malignancies: Current Status and the Future

Title: Reduced-Intensity Stem Cell Transplantation for Hematological Malignancies: Current Status and the Future

Volume: 2 Issue: 2

Author(s): Koji Kato, Yasser Khaled and Shin Mineishi

Affiliation:

Keywords: Reduced-intensity stem cell transplantation, graft-versus-host disease, graft-versus-leukemia effect, mixed chimerism, regimen-related toxicity

Abstract: Reduced-intensity stem cell transplantation (RIST) has opened a new era for hematopoietic stem cell transplantation (HSCT). It was developed based on the knowledge that graft-versus-tumor (GVT) effect is the main anti-tumor effect in allogeneic HSCT. Because RIST is associated with less morbidity and mortality, it can be applied to many patients who could not undergo conventional HSCT. Experiences in the last decade clarified many issues related to RIST. For example, graft-versus-host disease (GVHD) in RIST may differ in character compared to conventional HSCT. Also, it is now known that intensity of conditioning is important in disease control, and the optimal regimens may be different for each disease or for each disease status. There are still many unsolved questions, and large prospective randomized trials are necessary to resolve these.

Cite this article as:

Kato Koji, Khaled Yasser and Mineishi Shin, Reduced-Intensity Stem Cell Transplantation for Hematological Malignancies: Current Status and the Future, Current Stem Cell Research & Therapy 2007; 2 (2) . https://dx.doi.org/10.2174/157488807780599248