Synthesis of Alkyl β-D-Glcp-(1 3)-[ β-D-Glcp-(1 6)]-β-D-Glcp-(1 6)-β-DGlucopyranosides with Anti-Tumor Activity

Title: Synthesis of Alkyl β-D-Glcp-(1 3)-[ β-D-Glcp-(1 6)]-β-D-Glcp-(1 6)-β-DGlucopyranosides with Anti-Tumor Activity

Volume: 4 Issue: 2

Author(s): Linsen Heng, Qianfei Zhao, Xiangdong Mei, Haibin Lv, Xiaohui Jiang and Jun Ning

Affiliation:

Keywords: Carbohydrate, synthesis, oligosaccharide, glycosylation, trichloroacetimidate, anti-tumor

Abstract: Concise and effective synthesis of alkyl tetrasaccharides were achieved from the key intermediates alkyl 2,3,4-tri-benzoyl-β-D-glucopyranoside (5) and 2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl-(1→3)- [2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl-(1→6)]-2,4-di-O-acetyl-α-D-glucopyranosyl trichloroacetimidate (6), followed by deacylation. Bioassay of the inhibition of S180 noumenal tumors showed that alkyl tetrasaccharides could be employed as potential agent for cancer treatment.

Cite this article as:

Heng Linsen, Zhao Qianfei, Mei Xiangdong, Lv Haibin, Jiang Xiaohui and Ning Jun, Synthesis of Alkyl β-D-Glcp-(1 3)-[ β-D-Glcp-(1 6)]-β-D-Glcp-(1 6)-β-DGlucopyranosides with Anti-Tumor Activity, Letters in Organic Chemistry 2007; 4 (2) . https://dx.doi.org/10.2174/157017807780414172