Multicomponent Synthesis of 3,4-Dihydropyrimidin-2-(1H)-Ones with a Cu/Silica Xerogel Composite Catalyst

Dennis      Russowsky; Edilson   V.   Benvenutti; Gabriela   S.   Roxo; Fabio      Grasel

doi:10.2174/157017807780037496

Abstract

The efficient multicomponent synthesis of 3,4-dihydropyrimidin-2(1H)-ones promoted by a heterogeneous Cu/silica xerogel composite is presented herein. This composite was synthesized by the sol-gel methodology employing CuCl2 as the metal source. The catalyst can be easily recovered and reused in subsequent reactions.

Keywords: Biginelli reaction, dihydropyrimidinones, sol-gel, metal/silica composites, catalysis

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Letters in Organic Chemistry

Title: Multicomponent Synthesis of 3,4-Dihydropyrimidin-2-(1H)-Ones with a Cu/Silica Xerogel Composite Catalyst

Volume: 4 Issue: 1

Author(s): Dennis Russowsky, Edilson V. Benvenutti, Gabriela S. Roxo and Fabio Grasel

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Keywords: Biginelli reaction, dihydropyrimidinones, sol-gel, metal/silica composites, catalysis

Abstract: The efficient multicomponent synthesis of 3,4-dihydropyrimidin-2(1H)-ones promoted by a heterogeneous Cu/silica xerogel composite is presented herein. This composite was synthesized by the sol-gel methodology employing CuCl2 as the metal source. The catalyst can be easily recovered and reused in subsequent reactions.

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Russowsky Dennis, Benvenutti V. Edilson, Roxo S. Gabriela and Grasel Fabio, Multicomponent Synthesis of 3,4-Dihydropyrimidin-2-(1H)-Ones with a Cu/Silica Xerogel Composite Catalyst, Letters in Organic Chemistry 2007; 4 (1) . https://dx.doi.org/10.2174/157017807780037496