L-Proline as an Efficient Organo-Catalyst for the Synthesis of Polyhydroquinoline Via Multicomponent Hantzsch Reaction

Nandkishor   N.   Karade; Vishnu   H.   Budhewar; Sandeep   V.   Shinde; Wamanrao   N.   Jadhav

doi:10.2174/157017807780037405

Abstract

L-Proline has been found as an effective catalyst for the one pot synthesis of polyhydroquinoline derivatives via four component Hantzsch reaction. This method provides several advantages such as being environmentally benign, possessing high yields with increased variations of the substituents in the product and preparative simplicity.

Keywords: Hantzsch reaction, multi-component reactions, L-proline, polyhydroquinoline, β-dicarbonyl compound, aldehyde

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Letters in Organic Chemistry

Title: L-Proline as an Efficient Organo-Catalyst for the Synthesis of Polyhydroquinoline Via Multicomponent Hantzsch Reaction

Volume: 4 Issue: 1

Author(s): Nandkishor N. Karade, Vishnu H. Budhewar, Sandeep V. Shinde and Wamanrao N. Jadhav

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Keywords: Hantzsch reaction, multi-component reactions, L-proline, polyhydroquinoline, β-dicarbonyl compound, aldehyde

Abstract: L-Proline has been found as an effective catalyst for the one pot synthesis of polyhydroquinoline derivatives via four component Hantzsch reaction. This method provides several advantages such as being environmentally benign, possessing high yields with increased variations of the substituents in the product and preparative simplicity.

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Karade N. Nandkishor, Budhewar H. Vishnu, Shinde V. Sandeep and Jadhav N. Wamanrao, L-Proline as an Efficient Organo-Catalyst for the Synthesis of Polyhydroquinoline Via Multicomponent Hantzsch Reaction, Letters in Organic Chemistry 2007; 4 (1) . https://dx.doi.org/10.2174/157017807780037405