Oxazolidin-2-one Ring, a Popular Framework in Synthetic Organic Chemistry: Part 1. The Construction of the Oxazolidin-2-one Ring

G.      Zappia; E.      Gacs-Baitz; G.      Delle Monache; D.      Misiti; L.      Nevola; B.      Botta

doi:10.2174/157017907779981552

Abstract

The 1,3-oxazolidin-2-one nucleus is a popular heterocycle framework in synthetic organic chemistry, as well as in medicinal chemistry. This paper deals with the huge number of synthetic approaches addressed to the construction of this five-member ring, with a particular care for the mechanistic and stereochemical outcome.

Keywords: 1,3-Oxazolidin-2-one, cyclocarbamation reactions, 1,2-aminoalcohol, epoxides and aziridines, amino-acids, Curtius- rearrangement

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Current Organic Synthesis

Title: Oxazolidin-2-one Ring, a Popular Framework in Synthetic Organic Chemistry: Part 1. The Construction of the Oxazolidin-2-one Ring

Volume: 4 Issue: 1

Author(s): G. Zappia, E. Gacs-Baitz, G. Delle Monache, D. Misiti, L. Nevola and B. Botta

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Keywords: 1,3-Oxazolidin-2-one, cyclocarbamation reactions, 1,2-aminoalcohol, epoxides and aziridines, amino-acids, Curtius- rearrangement

Abstract: The 1,3-oxazolidin-2-one nucleus is a popular heterocycle framework in synthetic organic chemistry, as well as in medicinal chemistry. This paper deals with the huge number of synthetic approaches addressed to the construction of this five-member ring, with a particular care for the mechanistic and stereochemical outcome.

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Zappia G., Gacs-Baitz E., Delle Monache G., Misiti D., Nevola L. and Botta B., Oxazolidin-2-one Ring, a Popular Framework in Synthetic Organic Chemistry: Part 1. The Construction of the Oxazolidin-2-one Ring, Current Organic Synthesis 2007; 4 (1) . https://dx.doi.org/10.2174/157017907779981552