A Highly Efficient Low Temperature Modification of the Classical Ullmann Reaction

Frederic   R.   Leroux; Roger      Simon; Nathalie      Nicod

doi:10.2174/157017806779467979

Abstract

The efficient synthesis of sterically demanding tetra-substituted biaryls by means of a one-pot threestep low-temperature modification of the classical Ullmann reaction is reported. The major benefit of this methodology lies in the ready synthesis of polybrominated biaryls, which can be subsequently functionalized into various target molecules by means of regioselective halogen/metal permutations.

Keywords: Ullmann reaction, C-C coupling, aryllithium, copper

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Letters in Organic Chemistry

Title: A Highly Efficient Low Temperature Modification of the Classical Ullmann Reaction

Volume: 3 Issue: 12

Author(s): Frederic R. Leroux, Roger Simon and Nathalie Nicod

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Keywords: Ullmann reaction, C-C coupling, aryllithium, copper

Abstract: The efficient synthesis of sterically demanding tetra-substituted biaryls by means of a one-pot threestep low-temperature modification of the classical Ullmann reaction is reported. The major benefit of this methodology lies in the ready synthesis of polybrominated biaryls, which can be subsequently functionalized into various target molecules by means of regioselective halogen/metal permutations.

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Leroux R. Frederic, Simon Roger and Nicod Nathalie, A Highly Efficient Low Temperature Modification of the Classical Ullmann Reaction, Letters in Organic Chemistry 2006; 3 (12) . https://dx.doi.org/10.2174/157017806779467979