Novel One-Pot Synthesis of Amide Derivatives of Methylenebisphosphonate Utilizing the Mesyl Moiety as Leaving Group

Title: Novel One-Pot Synthesis of Amide Derivatives of Methylenebisphosphonate Utilizing the Mesyl Moiety as Leaving Group

Volume: 3 Issue: 12

Author(s): Jonna Jokiniemi, Markku Ahlgren and Jouko J. Vepsalainen

Affiliation:

Keywords: Bisphosphonate, amide esters, selective synthesis, mesyl leaving group, amination

Abstract: A novel one-pot synthesis was developed for the preparation of partial amide esters of (dichloromethylene)bisphosphonic acid from readily available tetramethyl ester with good selectivity and purity.

Cite this article as:

Jokiniemi Jonna, Ahlgren Markku and Vepsalainen J. Jouko, Novel One-Pot Synthesis of Amide Derivatives of Methylenebisphosphonate Utilizing the Mesyl Moiety as Leaving Group, Letters in Organic Chemistry 2006; 3 (12) . https://dx.doi.org/10.2174/157017806779467951