A Structural-Energetic Basis for B-Cell Epitope Prediction

Title: A Structural-Energetic Basis for B-Cell Epitope Prediction

Volume: 13 Issue: 7

Author(s): Salvador Eugenio C. Caoili

Affiliation:

Keywords: B-cell epitope prediction, antipeptide antibody, antiprotein antibody, peptide-protein cross-reactivity, structural energetics, solvent-accessible surface area

Abstract: Structural-energetic analysis of peptide and protein antigens in the context of binding to antibody reveals fundamental differences between the cross-reactions of antipeptide antibody with protein and antiprotein antibody with peptide, providing a physicochemical basis for B-cell epitope prediction as applied to the development of peptide-based vaccines and immunodiagnostics.

Cite this article as:

Caoili C. Salvador Eugenio, A Structural-Energetic Basis for B-Cell Epitope Prediction, Protein & Peptide Letters 2006; 13 (7) . https://dx.doi.org/10.2174/092986606777790502