An Efficient and Selective End-Modification of High-Molecular Weight Poly(Ethylene Glycol)s

Pietro      Campaner; Gian      Maria Bonora; Sara      Drioli

doi:10.2174/157017806779025942

Abstract

An innovative procedure aimed to the production of orthogonally protected amino-derivatives of high-molecular weight poly(ethylene glycol) (PEG) modified with linkers bearing differently reactive terminal amino groups is reported. This polymeric derivative represents a convenient, new soluble support particularly suitable as a drug delivery system of mixed molecules.

Keywords: Poly(ethylene glycol), PEG, polymer, conjugates, peptide, drug delivery

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Letters in Organic Chemistry

Title: An Efficient and Selective End-Modification of High-Molecular Weight Poly(Ethylene Glycol)s

Volume: 3 Issue: 10

Author(s): Pietro Campaner, Gian Maria Bonora and Sara Drioli

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Keywords: Poly(ethylene glycol), PEG, polymer, conjugates, peptide, drug delivery

Abstract: An innovative procedure aimed to the production of orthogonally protected amino-derivatives of high-molecular weight poly(ethylene glycol) (PEG) modified with linkers bearing differently reactive terminal amino groups is reported. This polymeric derivative represents a convenient, new soluble support particularly suitable as a drug delivery system of mixed molecules.

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Campaner Pietro, Maria Bonora Gian and Drioli Sara, An Efficient and Selective End-Modification of High-Molecular Weight Poly(Ethylene Glycol)s, Letters in Organic Chemistry 2006; 3 (10) . https://dx.doi.org/10.2174/157017806779025942