An Approach to Preparation of α-Hydroxyl Cyclobutanones from 1, 2-Bis(trimethylsiloxy)cyclobutene Catalyzed by MgI2 Etherate

Xingxian      Zhang

doi:10.2174/157017806779025988

Abstract

We describe an efficient and practical preparation of α-hydroxyl cyclobutanones from 1,2- Bis(trimethylsiloxy)cyclobutene (BTCB) with aromatic aldehydes, α,β-unsaturated aldehydes and their parent acetals catalyzed by 1-5 mol% of MgI2 etherate (MgI2•(OEt2)n) in dichloromethane under mild reaction conditions in good yields.

Keywords: α-Hydroxyl cyclobutanone, aldehyde, acetal, 1,2-bis(trimethylsiloxy)cyclobutene, MgI2 etherate

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Letters in Organic Chemistry

Title: An Approach to Preparation of α-Hydroxyl Cyclobutanones from 1, 2-Bis(trimethylsiloxy)cyclobutene Catalyzed by MgI2 Etherate

Volume: 3 Issue: 10

Author(s): Xingxian Zhang

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Keywords: α-Hydroxyl cyclobutanone, aldehyde, acetal, 1,2-bis(trimethylsiloxy)cyclobutene, MgI2 etherate

Abstract: We describe an efficient and practical preparation of α-hydroxyl cyclobutanones from 1,2- Bis(trimethylsiloxy)cyclobutene (BTCB) with aromatic aldehydes, α,β-unsaturated aldehydes and their parent acetals catalyzed by 1-5 mol% of MgI2 etherate (MgI2•(OEt2)n) in dichloromethane under mild reaction conditions in good yields.

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Zhang Xingxian, An Approach to Preparation of α-Hydroxyl Cyclobutanones from 1, 2-Bis(trimethylsiloxy)cyclobutene Catalyzed by MgI2 Etherate, Letters in Organic Chemistry 2006; 3 (10) . https://dx.doi.org/10.2174/157017806779025988