An Efficient Route to Thieno[2,3-d]pyrimidine Derivatives by Tandem [2,3] and [3,3] Sigmatropic Rearrangement (SUPPORTING DATA)

Krishna   C.   Majumdar; Nilasish      Pal; Sudip   K.   Chattopadhyay

doi:10.2174/157017806778700033

Abstract

Synthesis of biologically important thieno[2,3-d]pyrimidine derivatives 6a-f in 65-78% yields have been reported. The conditions applied here are based on the less studied tandem rearrangement protocol. The precursor sulfides in 73-85% were prepared from N,N-dimethyl-6-cholouracil and 1-aryloxy-4-chlorobut-2-yne by phase transfer catalyzed reaction condition.

Keywords: [2,3] and [3,3] sigmatropic rearrangement, m-chloroperoxybenzoic acid, thieno[2,3-d]pyrimidine

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Letters in Organic Chemistry

Title: An Efficient Route to Thieno[2,3-d]pyrimidine Derivatives by Tandem [2,3] and [3,3] Sigmatropic Rearrangement (SUPPORTING DATA)

Volume: 3 Issue: 9

Author(s): Krishna C. Majumdar, Nilasish Pal and Sudip K. Chattopadhyay

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Keywords: [2,3] and [3,3] sigmatropic rearrangement, m-chloroperoxybenzoic acid, thieno[2,3-d]pyrimidine

Abstract: Synthesis of biologically important thieno[2,3-d]pyrimidine derivatives 6a-f in 65-78% yields have been reported. The conditions applied here are based on the less studied tandem rearrangement protocol. The precursor sulfides in 73-85% were prepared from N,N-dimethyl-6-cholouracil and 1-aryloxy-4-chlorobut-2-yne by phase transfer catalyzed reaction condition.

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Majumdar C. Krishna, Pal Nilasish and Chattopadhyay K. Sudip, An Efficient Route to Thieno[2,3-d]pyrimidine Derivatives by Tandem [2,3] and [3,3] Sigmatropic Rearrangement (SUPPORTING DATA), Letters in Organic Chemistry 2006; 3 (9) . https://dx.doi.org/10.2174/157017806778700033