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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Facile Two-Step Chemo-Enzymatic Synthesis of GDP-Mannose

Author(s): Gang-Liang Huang, Xiang Liu, Hou-Cheng Zhang and Peng-George Wang

Volume 3, Issue 9, 2006

Page: [668 - 669] Pages: 2

DOI: 10.2174/157017806778700015

Price: $65

Abstract

Mannose is selectively converted into mannose-1-phosphate (Man-1-P, 1) without protection of the other hydroxyl groups by phosphorylation of the anomeric hydroxyl in dry tetrahydrofuran (THF) containing phosphoric acid. Compound 1 is activated with GTP and recombinant GDP-mannose pyrophosphorylase (GDPMan PP) to give GDP-Man 2.

Keywords: Man-1-P, GDP-Man, chemo-enzymatic synthesis, two-step


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