Abstract
A novel and convenient synthetic approach to ubiquinone-10 was reported via the SN2-type nucleophilic displacement reaction between copper-catalyzed Grignard reagent and the secondary allylic acetate, which was suitable for the large-scale production of ubiquinone-10.
Keywords: SN2'-type reaction, copper-catalyzed, Grignard reagent, secondary allylic acetate, regioselectivity, stereoselectivity
Letters in Organic Chemistry
Title: A Novel and Convenient Method for the Synthesis of Ubiquinone-10
Volume: 3 Issue: 8
Author(s): Feng Wang, Xiangrui Jiang, Lihong Hu, Shengyi Dong, Xiumei Wu, Hua Bai, Yongmin Zhang, Joachim Stockigt and Yu Zhao
Affiliation:
Keywords: SN2'-type reaction, copper-catalyzed, Grignard reagent, secondary allylic acetate, regioselectivity, stereoselectivity
Abstract: A novel and convenient synthetic approach to ubiquinone-10 was reported via the SN2-type nucleophilic displacement reaction between copper-catalyzed Grignard reagent and the secondary allylic acetate, which was suitable for the large-scale production of ubiquinone-10.
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Cite this article as:
Wang Feng, Jiang Xiangrui, Hu Lihong, Dong Shengyi, Wu Xiumei, Bai Hua, Zhang Yongmin, Stockigt Joachim and Zhao Yu, A Novel and Convenient Method for the Synthesis of Ubiquinone-10, Letters in Organic Chemistry 2006; 3 (8) . https://dx.doi.org/10.2174/157017806778559464
DOI https://dx.doi.org/10.2174/157017806778559464 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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