Stereoselective Synthesis of C3-C10 and C13-C21 Fragments of Laulimalide

Ajit      Chand Kunwar; Gangavaram   V.   M. Sharma; Anabathula      Prabhakar; Sreenivas      Punna

doi:10.2174/157017806777828411

Abstract

Synthesis of the C3-C10 and C13-C21 segments, having seven asymmetric centers of the marine macrolide, (-)-laulimalide is reported. The requisite stereogenic centers were generated on the chirons by the application of asymmetric reactions.

Keywords: intramolecular cyclization, chiron, stereoselective synthesis, Sharpless asymmetric epoxidation, laulimalide, Marine macrolide

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Letters in Organic Chemistry

Title: Stereoselective Synthesis of C3-C10 and C13-C21 Fragments of Laulimalide

Volume: 3 Issue: 6

Author(s): Ajit Chand Kunwar, Gangavaram V. M. Sharma, Anabathula Prabhakar and Sreenivas Punna

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Keywords: intramolecular cyclization, chiron, stereoselective synthesis, Sharpless asymmetric epoxidation, laulimalide, Marine macrolide

Abstract: Synthesis of the C3-C10 and C13-C21 segments, having seven asymmetric centers of the marine macrolide, (-)-laulimalide is reported. The requisite stereogenic centers were generated on the chirons by the application of asymmetric reactions.

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Chand Kunwar Ajit, M. Sharma V. Gangavaram, Prabhakar Anabathula and Punna Sreenivas, Stereoselective Synthesis of C3-C10 and C13-C21 Fragments of Laulimalide, Letters in Organic Chemistry 2006; 3 (6) . https://dx.doi.org/10.2174/157017806777828411