Synthesis and Biological Evaluation of Spirostanes Including Butyrolactone Moieties

Carlos   S.   Perez; Vivian      Leliebre-Lara; Odette      Concepcion; Francisco      Coll; Daniel   G.   Rivera; Orlando      Pando

doi:10.2174/157017806778341870

Abstract

Four new spirostanes functionalized with the butyrolactone moiety were efficiently synthesized and submitted to preliminary biological tests. Two practical synthetic routes were designed to enable the incorporation of the γ-lactone functionality into rings A and B. Butyrolactones 5 and 10 showed a promising plant growth-promoting activity which renders them good candidates for further biological studies.

Keywords: butyrolactones, biological activity, steroidal sapogenins, Steroids

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Letters in Organic Chemistry

Title: Synthesis and Biological Evaluation of Spirostanes Including Butyrolactone Moieties

Volume: 3 Issue: 7

Author(s): Carlos S. Perez, Vivian Leliebre-Lara, Odette Concepcion, Francisco Coll, Daniel G. Rivera and Orlando Pando

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Keywords: butyrolactones, biological activity, steroidal sapogenins, Steroids

Abstract: Four new spirostanes functionalized with the butyrolactone moiety were efficiently synthesized and submitted to preliminary biological tests. Two practical synthetic routes were designed to enable the incorporation of the γ-lactone functionality into rings A and B. Butyrolactones 5 and 10 showed a promising plant growth-promoting activity which renders them good candidates for further biological studies.

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Perez S. Carlos, Leliebre-Lara Vivian, Concepcion Odette, Coll Francisco, Rivera G. Daniel and Pando Orlando, Synthesis and Biological Evaluation of Spirostanes Including Butyrolactone Moieties, Letters in Organic Chemistry 2006; 3 (7) . https://dx.doi.org/10.2174/157017806778341870