Efficient Diastereoselective Titanium(IV) Reductive Amination of Ketones

Chanaz      Salmi; Yves      Letourneux; Jean   M.   Brunel

doi:10.2174/157017806776611971

Abstract

An efficient method for the diastereoselective synthesis of various secondary amines through a titanium(IV) isopropoxide-mediated reductive amination reaction of ketones is reported. Thus, a series of different ketones and (R)-Phenylethylamine were involved leading to the expected products in moderate to excellent yields and importantly in diastereoselectivities up to 100% in one case.

Keywords: Titanium, Reductive amination, Ketones, Secondary amines, Imines, Diastereoselectivity

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Letters in Organic Chemistry

Title: Efficient Diastereoselective Titanium(IV) Reductive Amination of Ketones

Volume: 3 Issue: 5

Author(s): Chanaz Salmi, Yves Letourneux and Jean M. Brunel

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Keywords: Titanium, Reductive amination, Ketones, Secondary amines, Imines, Diastereoselectivity

Abstract: An efficient method for the diastereoselective synthesis of various secondary amines through a titanium(IV) isopropoxide-mediated reductive amination reaction of ketones is reported. Thus, a series of different ketones and (R)-Phenylethylamine were involved leading to the expected products in moderate to excellent yields and importantly in diastereoselectivities up to 100% in one case.

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Salmi Chanaz, Letourneux Yves and Brunel M. Jean, Efficient Diastereoselective Titanium(IV) Reductive Amination of Ketones, Letters in Organic Chemistry 2006; 3 (5) . https://dx.doi.org/10.2174/157017806776611971