Efficacious Preparation of Biginelli Compounds. A Comparative Study of Different Reaction Techniques

Paramjit      Kaur; Sukhdeep      Singh; Kamaljit      Singh

doi:10.2174/157017806775789912

Abstract

A comparative study on various reaction techniques for the preparation of Biginelli compounds and a solvent-free sonication induced green approach through condensation of aldehydes, β-ketoester and urea/thiourea, catalyzed by an acid, to obtain title compounds in a synthetically useful manner is presented.

Keywords: calcium channel blockers, green chemistry, 3,4-dihydropyrimidinones, sonication, Biginelli compounds

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Letters in Organic Chemistry

Title: Efficacious Preparation of Biginelli Compounds. A Comparative Study of Different Reaction Techniques

Volume: 3 Issue: 3

Author(s): Paramjit Kaur, Sukhdeep Singh and Kamaljit Singh

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Keywords: calcium channel blockers, green chemistry, 3,4-dihydropyrimidinones, sonication, Biginelli compounds

Abstract: A comparative study on various reaction techniques for the preparation of Biginelli compounds and a solvent-free sonication induced green approach through condensation of aldehydes, β-ketoester and urea/thiourea, catalyzed by an acid, to obtain title compounds in a synthetically useful manner is presented.

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Kaur Paramjit, Singh Sukhdeep and Singh Kamaljit, Efficacious Preparation of Biginelli Compounds. A Comparative Study of Different Reaction Techniques, Letters in Organic Chemistry 2006; 3 (3) . https://dx.doi.org/10.2174/157017806775789912