One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Hydrochloric Acid- β-Cyclodextrin- Combined Catalysts

Title: One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Hydrochloric Acid- β-Cyclodextrin- Combined Catalysts

Volume: 3 Issue: 3

Author(s): Genxiang Luo, Chunsheng Liu, Haixia Zhou and Miao He

Affiliation:

Keywords: Biginelli reaction, Dihydropyrimidinones, β-cyclodextrin, One-pot, Synthesis

Abstract: An improved approach has been found to carry out the Biginelli reaction for the synthesis of 3,4- dihydropyrimidin- 2(1H)-one derivatives. This synthesis was performed in the presence of hydrochloric acid and β-cyclodextrin in ethanol solution. Compared with the classical Biginelli reaction conditions, this new approach has the advantage of excellent yields and short reaction time.

Cite this article as:

Luo Genxiang, Liu Chunsheng, Zhou Haixia and He Miao, One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Hydrochloric Acid- β-Cyclodextrin- Combined Catalysts, Letters in Organic Chemistry 2006; 3 (3) . https://dx.doi.org/10.2174/157017806775789985