Efficient Synthesis of Various Secondary Amines Through a Titanium(IV) isopropoxide-Mediated Reductive Amination of Ketones

Title: Efficient Synthesis of Various Secondary Amines Through a Titanium(IV) isopropoxide-Mediated Reductive Amination of Ketones

Volume: 3 Issue: 5

Author(s): Chanaz Salmi, Yves Letourneux and Jean M. Brunel

Affiliation:

Keywords: Titanium, reductive amination, ketones, secondary amines, imines

Abstract: An efficient method for the synthesis of various secondary amines through a titanium(IV)- isopropoxide-mediated reductive amination reaction of ketones is reported. Thus, a series of different ketones and amines were involved leading to the expected products in moderate to excellent yields up to 98% in numerous cases. The mechanistic rationale of this reaction has been demonstrated through 1H and 13C NMR experiments and occurs exclusively via the formation of a transient imine species.

Cite this article as:

Salmi Chanaz, Letourneux Yves and Brunel M. Jean, Efficient Synthesis of Various Secondary Amines Through a Titanium(IV) isopropoxide-Mediated Reductive Amination of Ketones, Letters in Organic Chemistry 2006; 3 (5) . https://dx.doi.org/10.2174/157017806776611845