The Prediction of Hydrophobicity Gradients within Membrane Interactive Protein α-Helices Using a Novel Graphical Technique

Frederick      Harris; Sarah      Dennison; David   A   Phoenix

doi:10.2174/092986606777145832

Abstract

Here, it is shown that amphiphilicity profiling based on the mean hydrophobic moment provides a simple visual guide for the identification of oblique orientated a-helices. The methodology has an efficiency of circa 70% and predicts that approximately 40% of transmembrane a-helices may possess these structures.

Keywords: Oblique orientated α-helix, hydrophobicity gradient, hydropathy plot analysis, hydrophobic moment, amphiphilic profiling, transmembrane protein

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Protein & Peptide Letters

Title: The Prediction of Hydrophobicity Gradients within Membrane Interactive Protein α-Helices Using a Novel Graphical Technique

Volume: 13 Issue: 6

Author(s): Frederick Harris, Sarah Dennison and David A Phoenix

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Keywords: Oblique orientated α-helix, hydrophobicity gradient, hydropathy plot analysis, hydrophobic moment, amphiphilic profiling, transmembrane protein

Abstract: Here, it is shown that amphiphilicity profiling based on the mean hydrophobic moment provides a simple visual guide for the identification of oblique orientated a-helices. The methodology has an efficiency of circa 70% and predicts that approximately 40% of transmembrane a-helices may possess these structures.

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Harris Frederick, Dennison Sarah and Phoenix A David, The Prediction of Hydrophobicity Gradients within Membrane Interactive Protein α-Helices Using a Novel Graphical Technique, Protein & Peptide Letters 2006; 13 (6) . https://dx.doi.org/10.2174/092986606777145832