HIV-1 RNase H: Recent Progress in an Exciting, yet Little Explored, Drug Target

Enzo      Tramontano

doi:10.2174/138955706777435733

Abstract

HIV-1 reverse transcriptase-associated ribonuclease H (RNase H) is an attractive non traditional target for drug development which has been, so far, little explored. All drugs shown to inhibit HIV-1 RNase H are reported, including the recently described classes of compounds that interact with the metal ions in the active site.

Keywords: HIV-1, Reverse transcriptase, Ribonuclease H, Inhibition, Drug development, N-hydroxyimides, Diketo acids

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Mini-Reviews in Medicinal Chemistry

Title: HIV-1 RNase H: Recent Progress in an Exciting, yet Little Explored, Drug Target

Volume: 6 Issue: 6

Author(s): Enzo Tramontano

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Keywords: HIV-1, Reverse transcriptase, Ribonuclease H, Inhibition, Drug development, N-hydroxyimides, Diketo acids

Abstract: HIV-1 reverse transcriptase-associated ribonuclease H (RNase H) is an attractive non traditional target for drug development which has been, so far, little explored. All drugs shown to inhibit HIV-1 RNase H are reported, including the recently described classes of compounds that interact with the metal ions in the active site.

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Tramontano Enzo, HIV-1 RNase H: Recent Progress in an Exciting, yet Little Explored, Drug Target, Mini-Reviews in Medicinal Chemistry 2006; 6 (6) . https://dx.doi.org/10.2174/138955706777435733