Ceramide Involvement in Apoptosis and Apoptotic Diseases

Title: Ceramide Involvement in Apoptosis and Apoptotic Diseases

Volume: 6 Issue: 6

Author(s): Karin Thevissen, Isabelle E.J.A. Francois, Joris Winderickx, Christophe Pannecouque and Bruno P.A. Cammue

Affiliation:

Keywords: Neurodegenerative disease, anthrapyrazolone, pyridinyl imidazole, methoxyflavone

Abstract: Apoptosis is implicated in a number of diseases, including neurodegenerative diseases and AIDS. More and more, evidence is accumulating pointing to the critical role of ceramides in the induction of apoptosis. The present review summarizes (i) the molecular basis and regulation of the apoptotic machinery, (ii) the molecular role of ceramides in the induction or execution of apoptotic pathways, and (iii) evidence linking ceramide generation to various apoptotic diseases. Additionally, this review discusses putative therapeutic approaches inhibiting ceramide production in apoptotic diseases.

Cite this article as:

Thevissen Karin, Francois E.J.A. Isabelle, Winderickx Joris, Pannecouque Christophe and Cammue P.A. Bruno, Ceramide Involvement in Apoptosis and Apoptotic Diseases, Mini-Reviews in Medicinal Chemistry 2006; 6 (6) . https://dx.doi.org/10.2174/138955706777435643