Coagulation and Sepsis

Title: Coagulation and Sepsis

Volume: 6 Issue: 2

Author(s): F. R. Machado and E. Silva

Affiliation:

Keywords: Sepsis, coagulation, fibrinolysis, activated protein C, antithrombin, tissue factor

Abstract: Sepsis is a complex disease and coagulation derangements are part of this context. The inflammatory storm is ultimately responsible for coagulation derangements. It is characterized by exacerbated coagulation, impaired anticoagulation and decreased fibrin removal. These derangements are implicated in the generation of microcirculation thrombosis, with deposition of microclots and obstruction of circulation, impairing blood flow and contributing to tissue hypoperfusion and consequently, organ dysfunction. This review will address the main issues regarding coagulation disorders in the context of sepsis.

Cite this article as:

Machado R. F. and Silva E., Coagulation and Sepsis, Endocrine, Metabolic & Immune Disorders - Drug Targets 2006; 6 (2) . https://dx.doi.org/10.2174/187153006777442369