New Insights into Redox-Modulated Cell Signaling

Title: New Insights into Redox-Modulated Cell Signaling

Volume: 17 Issue: 36

Author(s): Gabriella Leonarduzzi, Barbara Sottero, Gabriella Gabriella Testa, Fiorella Biasi and Giuseppe Poli

Affiliation:

Keywords: Reactive oxygen species, oxidative stress, cell signaling, kinases, phosphatases, transcription factors, urokinase plasminogen activator, Arachidonic acid, tumorigenesis, H2O2

Abstract: The complex system of molecular communications underlying cell biochemistry and function involves numerous components including kinases, phosphatases and transcription factors, which are known to be sensitive to cellular and tissue redox changes. Reactive oxygen species (ROS), whose constitutive generation in cells and tissues is amplified under pro-oxidant conditions, are now unanimously recognized to be important triggers and modulators of cell signaling, and consequently of cell behavior. This review considers the major signaling pathways that mediate gene regulation in response to ROS.

Cite this article as:

Leonarduzzi Gabriella, Sottero Barbara, Gabriella Testa Gabriella, Biasi Fiorella and Poli Giuseppe, New Insights into Redox-Modulated Cell Signaling, Current Pharmaceutical Design 2011; 17 (36) . https://dx.doi.org/10.2174/138161211798764906