The Hedgehog Knows Many Tricks

Title: The Hedgehog Knows Many Tricks

Volume: 12 Issue: 14

Author(s): Glen J. Weiss, Alain C. Mita and Daniel D. Von Hoff

Affiliation:

Keywords: Hedgehog pathway, cancer, treatment, mutation, autocrine, paracrine, signaling, clinical trial, carcinogenesis, PTCH1

Abstract: Contrary to the Classical Greek poet Archilochus phrase “The fox knows many things but the hedgehog knows one big thing”, the Hedgehog (HH) signaling pathway knows at least 3 ways to promote or support carcinogenesis. In this review, we provide a summary of the HH signaling pathway, and detail the clinical relevance and treatment of patients. Finally, future directions in exploiting this promising pathway will be addressed.

Cite this article as:

J. Weiss Glen, C. Mita Alain and D. Von Hoff Daniel, The Hedgehog Knows Many Tricks, Current Drug Targets 2011; 12 (14) . https://dx.doi.org/10.2174/138945011798829429