Metastasis Suppressors: Basic and Translational Advances

Title: Metastasis Suppressors: Basic and Translational Advances

Volume: 12 Issue: 11

Author(s): C. Buchanan, M. A. Lago Huvelle and M. G. Peters

Affiliation:

Keywords: Metastasis suppressor genes, metastatic cascade, suppressor-based therapies, cancer cell types, colonize ectopic tissue, metastatic process, Paget hypothesized, Innumerable oncogenes, amino acids, human genome, oral squamous cells, metastatic melanoma, Simpson-Golabi-Behmel syndrome (SGBS), micrometastatic tumor cells

Abstract: Tumor metastasis is a main contributor to death in cancer patients. In the last years, a new class of molecules that reduces the metastatic propensity has been identified: metastasis suppressors. These proteins regulate multiple steps in the metastatic cascade, including cell invasion, survival in the vascular and lymphatic circulation, and colonization of distant organ sites. As a consequence, they are very important therapeutic targets. This review discusses our current understanding of metastasis suppressors and how this knowledge might be useful to improve the treatment of cancer patients.

Cite this article as:

Buchanan C., A. Lago Huvelle M. and G. Peters M., Metastasis Suppressors: Basic and Translational Advances, Current Pharmaceutical Biotechnology 2011; 12 (11) . https://dx.doi.org/10.2174/138920111798376914