Abstract
Asymmetric Mannich-type reactions are important organic transformations that provide excellent protocols for the synthesis of optically active nitrogen-containing compounds. This article provides an overview on the development of thiourea-catalyzed asymmetric Mannich or nitro-Mannich reactions including scope, limitations, and applications of different catalytic systems.
Keywords: Thiourea, Mannich-type reaction, asymmetric catalysis, organocatalysis, organocatalytic, organic chemistry, stereoselective catalysis, hydrogen-bonding donors, monothiourea, bis-thiourea, b-amino acids, Lewis basic, Isoquinolines, Wittig Reaction, Nitro-Mannich
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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