Recent Advance in Aminopeptidase N (APN/CD13) Inhibitor Research

Title: Recent Advance in Aminopeptidase N (APN/CD13) Inhibitor Research

Volume: 18 Issue: 32

Author(s): X. Zhang, H. Fang, J. Zhang, Y. Yuan and W. Xu

Affiliation:

Keywords: Aminopeptidase N, rational drug design, inhibitors, peptidomimetics, anti-tumor, structure activity relationship

Abstract: APN is an important zinc dependent metallo-exopeptidase, which can degrade the extracellular matrix, and plays an important role in tumor invasion, metastasis and angiogenesis. it has been considered as a suitable target for anti-cancer drug design. Recently, research of structure-based APN inhibitors is becoming an interesting field, and many APN inhibitors have been reported. Here we review a series of APN inhibitors and the recent progress in this field.

Cite this article as:

Zhang X., Fang H., Zhang J., Yuan Y. and Xu W., Recent Advance in Aminopeptidase N (APN/CD13) Inhibitor Research, Current Medicinal Chemistry 2011; 18 (32) . https://dx.doi.org/10.2174/092986711797535155