Alkaloids and Flavonoids as α1-Adrenergic Receptor Antagonists

Title: Alkaloids and Flavonoids as α1-Adrenergic Receptor Antagonists

Volume: 18 Issue: 32

Author(s): W. Li, L. Du and M. Li

Affiliation:

Keywords: α1-adrenergic receptor, antagonist, natural products, alkaloids, flavonoids, homologous GPCRs, vasodilatation, transmembrane domains, G proteins, pharmacological properties

Abstract: Since the subtypes of α1-adrenergic receptor have been thoroughly determined, to date medicinal chemists raise their deliberation on how to conceive selective α1-adrenergic receptor antagonist with the minimal side effects. It needs to be well recognized that natural products can exist as a significant source of drug leads, thus portraying a consequential capacity in drug design and development. The current review article would like to present a comprehensive survey on natural products, mainly including alkaloids and flavonoids, which exhibit α1-adrenergic receptor antagonistic activities.

Cite this article as:

Li W., Du L. and Li M., Alkaloids and Flavonoids as α1-Adrenergic Receptor Antagonists, Current Medicinal Chemistry 2011; 18 (32) . https://dx.doi.org/10.2174/092986711797535209