Pharmacological and Clinical Studies on Purine Nucleoside Analogs- New Anticancer Agents

Title: Pharmacological and Clinical Studies on Purine Nucleoside Analogs- New Anticancer Agents

Volume: 6 Issue: 5

Author(s): E. Lech-Maranda, A. Korycka and T. Robak

Affiliation:

Keywords: Cladribine, fludarabine, pentostatin, clofarabine, nelarabine, immucillin H

Abstract: More recently, three novel purine nucleoside analogs, including clofarabine, nelarabine and immucillin H, have been introduced into clinical trials. These agents have different metabolic properties, novel mechanism of action, and are undergoing phase I-II clinical studies for the treatment of hematopoietic malignancies. Pharmacology and anticancer activity of PNA are the subjects of this review.

Cite this article as:

Lech-Maranda E., Korycka A. and Robak T., Pharmacological and Clinical Studies on Purine Nucleoside Analogs- New Anticancer Agents, Mini-Reviews in Medicinal Chemistry 2006; 6 (5) . https://dx.doi.org/10.2174/138955706776876212