A Rapid, Four-Component Synthesis of Functionalized Thiazoles

Maryam      Sabbaghan; Mostafa      Alidoust; Zinatossadat      Hossaini

doi:10.2174/138620711796957134

Abstract

An efficient synthesis of 2-(dialkylamino)-4-phenyl)-1,3-thiazol-5-yl)(phenyl)methanone using acid chlorides, secondary amines, 2-bromoacethophenone and ammonium thiocyanate is described.

Keywords: Thiazole, Hantzsch synthesis, 2-Bromoacethophenone, Aroyl isothiocyanate, Secondary amine, acid chlorides, heterocycle, estrogen receptors, fungicides, drugs

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Combinatorial Chemistry & High Throughput Screening

Title: A Rapid, Four-Component Synthesis of Functionalized Thiazoles

Volume: 14 Issue: 9

Author(s): Maryam Sabbaghan, Mostafa Alidoust and Zinatossadat Hossaini

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Keywords: Thiazole, Hantzsch synthesis, 2-Bromoacethophenone, Aroyl isothiocyanate, Secondary amine, acid chlorides, heterocycle, estrogen receptors, fungicides, drugs

Abstract: An efficient synthesis of 2-(dialkylamino)-4-phenyl)-1,3-thiazol-5-yl)(phenyl)methanone using acid chlorides, secondary amines, 2-bromoacethophenone and ammonium thiocyanate is described.

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Sabbaghan Maryam, Alidoust Mostafa and Hossaini Zinatossadat, A Rapid, Four-Component Synthesis of Functionalized Thiazoles, Combinatorial Chemistry & High Throughput Screening 2011; 14 (9) . https://dx.doi.org/10.2174/138620711796957134