Recent Advances in Anti-Influenza Agents with Neuraminidase as Target

Title: Recent Advances in Anti-Influenza Agents with Neuraminidase as Target

Volume: 6 Issue: 4

Author(s): Jie Zhang and Wenfang Xu

Affiliation:

Keywords: Influenza, influenza virus, neuraminidase (NA), neuraminidase inhibitors (NAIs), sialic acid (SA), anti-influenza agents, antiviral, advances

Abstract: Neuraminidase (NA) is the major surface glycoprotein of the influenza virus. It has been considered a suitable target for designing agents against influenza viruses. Rational drug design of NA inhibitors is now in the clinic and is effective for the treatment of influenza. Recently, research of structure-based NA inhibitors is becoming an interesting field, leading to a breakthrough in the control of influenza. Here we review a series of neuraminidase inhibitors and the recent progress in this field.

Cite this article as:

Zhang Jie and Xu Wenfang, Recent Advances in Anti-Influenza Agents with Neuraminidase as Target, Mini-Reviews in Medicinal Chemistry 2006; 6 (4) . https://dx.doi.org/10.2174/138955706776361475