The gp130 Receptor Cytokine Family: Regulators of Adipocyte Development and Function

Title: The gp130 Receptor Cytokine Family: Regulators of Adipocyte Development and Function

Volume: 17 Issue: 4

Author(s): Ursula A. White and Jacqueline M. Stephens

Affiliation:

Keywords: Adipocyte, gp130, STAT3, IL-6, OSM, LIF, CT-1

Abstract: Gp130 cytokines are involved in the regulation of numerous biological processes, including hematopoiesis, immune response, inflammation, cardiovascular action, and neuronal survival. These cytokines share glycoprotein 130 as a common signal transducer in their receptor complex and typically activate STAT3. Most gp130 cytokines have paracrine or endocrine actions, and their levels can be measured in circulation in rodents and humans. In recent years, various laboratories have conducted studies to demonstrate that gp130 cytokines can modulate adipocyte development and function. Therefore, these studies suggest that some gp130 cytokines may be viable anti-obesity therapeutics. In this review, we will summarize the reported effects of gp130 cytokines on adipocyte differentiation and adipocyte function. In addition, the modulation of gp130 cytokines in conditions of obesity, insulin resistance, and Type 2 diabetes will be presented.

Cite this article as:

A. White Ursula and M. Stephens Jacqueline, The gp130 Receptor Cytokine Family: Regulators of Adipocyte Development and Function, Current Pharmaceutical Design 2011; 17 (4) . https://dx.doi.org/10.2174/138161211795164202