Unusual Amino Acids: Synthesis and Introduction into Naturally Occurring Peptides and Biologically Active Analogues

Title: Unusual Amino Acids: Synthesis and Introduction into Naturally Occurring Peptides and Biologically Active Analogues

Volume: 6 Issue: 3

Author(s): G. Cardillo, L. Gentilucci and A. Tolomelli

Affiliation:

Keywords: Unusual amino acids, peptides, peptidomimetics, aziridines, α-substituted-β-amino acids, β-substituted-?-amino acids, endomorphin, lysobactin

Abstract: This review covers our recent advances in the synthesis of unusual amino acids in optically pure form, and their introduction into naturally occurring peptides with specific biological properties, or into modified bioactive peptides, aiming to obtain analogues displaying enhanced performances in term of activity, bioavailability and resistance to enzymatic hydrolysis.

Cite this article as:

Cardillo G., Gentilucci L. and Tolomelli A., Unusual Amino Acids: Synthesis and Introduction into Naturally Occurring Peptides and Biologically Active Analogues, Mini-Reviews in Medicinal Chemistry 2006; 6 (3) . https://dx.doi.org/10.2174/138955706776073394