Targeting Double Stranded DNA with Peptide Nucleic Acid (PNA)

Peter      E. Nielsen

doi:10.2174/0929867003373373

Abstract

PNA (peptide nucleic acid) is a DNA mimic with a pseudopeptide (polyamide) backbone which can be used to target double stranded DNA with high sequence specificity. PNA therefore has great potential in the development of biomolecular tools for manipulation of DNA as well as for the development of DNA targeted gene therapeutic drugs. The status of this field is discussed in terms of PNA binding modes and mechanism as well as applications.

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Current Medicinal Chemistry

Title: Targeting Double Stranded DNA with Peptide Nucleic Acid (PNA)

Volume: 8 Issue: 5

Author(s): Peter E. Nielsen

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Abstract: PNA (peptide nucleic acid) is a DNA mimic with a pseudopeptide (polyamide) backbone which can be used to target double stranded DNA with high sequence specificity. PNA therefore has great potential in the development of biomolecular tools for manipulation of DNA as well as for the development of DNA targeted gene therapeutic drugs. The status of this field is discussed in terms of PNA binding modes and mechanism as well as applications.

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E. Nielsen Peter, Targeting Double Stranded DNA with Peptide Nucleic Acid (PNA), Current Medicinal Chemistry 2001; 8 (5) . https://dx.doi.org/10.2174/0929867003373373