Combinatorial Synthesis of 3,5-Dimethylene Substituted 1,2,4-Triazoles

Scott      S. Woodard; Kevin      D. Jerome

doi:10.2174/138620711794474033

Abstract

Combinatorial cyclizations of imidates and hydrazides with methylene linked R groups, generated from the corresponding nitriles and carboxylic acids, respectively, provided a large library of 3,5-dimethylene substituted 1,2,4- trizoles.

Keywords: Cyclizations, combinatorial chemistry, 1,2,4-triazoles, Pinner reaction, hydrazides, imidates, Amberlyst A-21, Methyl imidate HCl, Benzyl imidate, acetonitrile, H NMR, Isovaleroic hydrazide

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Combinatorial Chemistry & High Throughput Screening

Title: Combinatorial Synthesis of 3,5-Dimethylene Substituted 1,2,4-Triazoles

Volume: 14 Issue: 2

Author(s): Scott S. Woodard and Kevin D. Jerome

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Abstract: Combinatorial cyclizations of imidates and hydrazides with methylene linked R groups, generated from the corresponding nitriles and carboxylic acids, respectively, provided a large library of 3,5-dimethylene substituted 1,2,4- trizoles.

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S. Woodard Scott and D. Jerome Kevin, Combinatorial Synthesis of 3,5-Dimethylene Substituted 1,2,4-Triazoles, Combinatorial Chemistry & High Throughput Screening 2011; 14 (2) . https://dx.doi.org/10.2174/138620711794474033