From Substance Dependence to Addiction: Impact of a Conceptual Shift on Therapeutic Approaches?

Michel      Reynaud; Laurent      Karila

doi:10.2174/138161211796150800

Abstract

Switching from the concept of substance or alcohol dependence to that of addiction has profoundly modified our ways of approaching, treating and organizing the care of this disease. This more complex and subtle approach gives less importance to the substance and its effects and focuses more on the initiation of pathological behavior. It is important to keep in mind that the addictive process associates a substance (more or less addictive), an individual (more or less vulnerable) and an environment (more or less condoning). Today, it is no longer possible to consider that a drug acts on only one receptor or one system. Current understanding of inner regulation mechanisms integrates the interactions between the various stimulated brain pathways. Addiction treatments which should benefit from advances in genetics, neuropsychology and neuroimaging could be increasingly individualized in the years to come. The “addictology” approach has triggered thinking about other therapeutic approaches such as modification of therapeutic objectives toward “risk reductions” or applying this model to behavioral addictions (food, sex, sport, gaming…)

Keywords: Addiction, individual vulnerability, behavioural, environment, DSM-V, neuropsychology, neuroimaging, addictology, vulnerable, polysubstance, epigenetic, psychology, acetylcholine, neurokinine, glutamate, medications, diagnostic, pertinent, polymorphisms