MDMA Administration and Heat Shock Proteins Response: Foreseeing a Molecular Link

Title: MDMA Administration and Heat Shock Proteins Response: Foreseeing a Molecular Link

Volume: 11 Issue: 5

Author(s): C. Pomara, S. D'Errico, L. Zummo, F. Cappello and G. Li Volti

Affiliation:

Keywords: 3,4-Methylenedioxy-N-methylamphetamine, brain toxicity, Hsp27, Hsp32, Hsp60, Hsp70

Abstract: Molecular and cellular mechanisms of MDMA-induced toxicity have been extensively studied in a number of experimental models. Nevertheless, only few studies investigated the involvement of HSPs (“molecular chaperones”) in MDMA organs toxicity. In the present minireview we highlight this subject analysing the results of these studies conducted especially on brain tissue. Despite of it seems obvious that HSPs overexpression is a protective reaction against MDMA treatment, the molecular mechanisms for exerting their action are far to be undiscovered. At the same time, we need of comprehensive studies concerning the whole range of Hsps/chaperones expressions in all organs after acute and chronic administration of MDMA.

Cite this article as:

Pomara C., D'Errico S., Zummo L., Cappello F. and Li Volti G., MDMA Administration and Heat Shock Proteins Response: Foreseeing a Molecular Link, Current Pharmaceutical Biotechnology 2010; 11 (5) . https://dx.doi.org/10.2174/138920110791591445