Combination of Electrochemical, Spectrometric and Other Analytical Techniques for High Throughput Screening of Pharmaceutically Active Compounds

Title: Combination of Electrochemical, Spectrometric and Other Analytical Techniques for High Throughput Screening of Pharmaceutically Active Compounds

Volume: 13 Issue: 7

Author(s): Sibel Suzen and Sibel A. Ozkan

Affiliation:

Keywords: Electrochemistry, voltammetry, mass spectrometry, HPLC, chemiluminescence

Abstract: Recently, the use of electrochemistry and combination of this method with spectroscopic and other analytical techniques are becoming one of the important approaches in drug discovery and research as well as quality control, drug stability, determination of physiological activity, and measurement of neurotransmitters. Many fundamental physiological processes depend on oxido-reduction reactions in the body. Therefore, it may be possible to find connections between electrochemical and biochemical reactions concerning electron transfer pathways. Applications of electrochemical techniques to redox-active drug development and studies are one of the recent interests in drug discovery. In this review, the latest developments related to the use of electrochemical techniques in drug research will be surveyed in order to evaluate possible combinations of spectrometric methods with electrochemical techniques.

Cite this article as:

Suzen Sibel and A. Ozkan Sibel, Combination of Electrochemical, Spectrometric and Other Analytical Techniques for High Throughput Screening of Pharmaceutically Active Compounds, Combinatorial Chemistry & High Throughput Screening 2010; 13 (7) . https://dx.doi.org/10.2174/1386207311004070658