Glycine Transporter Inhibitors as Therapeutic Agents for Schizophrenia

Title: Glycine Transporter Inhibitors as Therapeutic Agents for Schizophrenia

Volume: 1 Issue: 1

Author(s): Kenji Hashimoto

Affiliation:

Keywords: NMDA receptor, glycine, glycine transporter, glia, cognition, schizophrenia

Abstract: Multiple lines of evidence suggest that a dysfunction in the glutamatergic neurotransmission via the N-methyl- D-aspartate (NMDA) receptors contributes to the pathophysiology of psychiatric diseases including schizophrenia. The potentiation of NMDA receptor function may be a useful approach for the treatment of diseases associated with NMDA receptor hypofunction. One possible strategy is to increase synaptic levels of glycine by blocking the glycine transporter-1 (GlyT-1) in glia cells, since glycine acts as a co-agonist site on the NMDA receptor. In this article, the author reviews the recent important patents on GlyT-1 inhibitors for treatment of schizophrenia and other psychiatric diseases associated with the NMDA receptor hypofunction.

Cite this article as:

Hashimoto Kenji, Glycine Transporter Inhibitors as Therapeutic Agents for Schizophrenia, Recent Patents on CNS Drug Discovery (Discontinued) 2006; 1 (1) . https://dx.doi.org/10.2174/157488906775245336