Novel Natural and Synthetic Ligands of the Endocannabinoid System

Title: Novel Natural and Synthetic Ligands of the Endocannabinoid System

Volume: 17 Issue: 14

Author(s): Lumir O. Hanus and Raphael Mechoulam

Affiliation:

Keywords: CB agonists, Endocannabinoids, CB antagonists, FAAH, MGL, DAGL

Abstract: In this review we describe recent advances in the chemistry of novel CB1/CB2 agonists, CB1 antagonists, selective CB2 agonists, fatty acid amide hydrolase inibitors, monoglyceride (MGL) and diglyceride (DAGL) inhibitors and cannabinoid-type agonists and antagonists of non CB1/CB2 receptors. In view of recent interest in the activities of fatty acid amides of amino acids (N-acyl amino acids) a list of this type of compounds was compiled and is presented as a Table. We conclude that further synthetic work based on both the plant cannabinoids and on the endocannabinoids may lead to novel therapeutics and that the identification and the elucidation of the biological profile of the myriad of endogenous N-acyl amino acids and related compounds may enhance the already wide spectrum of lipidomics.

Cite this article as:

Hanus O. Lumir and Mechoulam Raphael, Novel Natural and Synthetic Ligands of the Endocannabinoid System, Current Medicinal Chemistry 2010; 17 (14) . https://dx.doi.org/10.2174/092986710790980096