Abstract
The use of emerging multicomponent reactions (MCRs) in conjunction with microwave (MW)-assisted chemistry techniques is dramatically reducing chemical waste and reaction times in several organic syntheses and chemical transformations. The MW-assisted MCRs offer rapid and efficient procedures for the introduction of many points of structural diversity into heterocyclic compounds prepared in a straightforward manner in a single synthetic step. The present review summarizes recent developments in MW-assisted MCRs for the construction of five-, six-, and seven-membered heterocyclic skeletons as well as dicyclic system. Methods for the generation of both simple and fused heterocyclic targets are described, with particular emphasis on the introduction of structural diversity and complexity. In many cases, MW-assisted MCRs offer considerable improvements in selectivity, chemical yield and purity and constitute a very simple and extremely rapid method to access a diverse range of heterocyclic motifs.
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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