The Role of Fibroblast Growth Factor 21 (FGF21) on Energy Balance, Glucose and Lipid Metabolism

Title: The Role of Fibroblast Growth Factor 21 (FGF21) on Energy Balance, Glucose and Lipid Metabolism

Volume: 5 Issue: 4

Author(s): Daniel Cuevas-Ramos, Paloma Almeda-Valdes, Carlos A. Aguilar-Salinas, Gabriel Cuevas-Ramos, Andres A. Cuevas-Sosa and Francisco J. Gomez-Perez

Affiliation:

Keywords: Fibroblast growth factor 21, Glucose, Energy balance, Insulin, Metabolic syndrome, Type 2 diabetes mellitus

Abstract: FGF21 is a novel member of the FGFs family, is mainly expressed in liver and it functions as a potent activator of glucose uptake on adipocytes. When over expressed in transgenic mice, it protects animals from diet-induced obesity and its administration to diabetic rodents and monkeys lowers blood glucose and triglyceride levels. Recently, increased levels of FGF21 have been identified as an independent risk factor related with metabolic syndrome. A review of the relevant roles of FGF21 in metabolism is presented here.

Cite this article as:

Cuevas-Ramos Daniel, Almeda-Valdes Paloma, Aguilar-Salinas A. Carlos, Cuevas-Ramos Gabriel, Cuevas-Sosa A. Andres and Gomez-Perez J. Francisco, The Role of Fibroblast Growth Factor 21 (FGF21) on Energy Balance, Glucose and Lipid Metabolism, Current Diabetes Reviews 2009; 5 (4) . https://dx.doi.org/10.2174/157339909789804396