Recent Developments in the Chemistry of Thebaine and its Transformation Products as Pharmacological Targets

Title: Recent Developments in the Chemistry of Thebaine and its Transformation Products as Pharmacological Targets

Volume: 16 Issue: 25

Author(s): Sandor Berenyi, Csaba Csutoras and Attila Sipos

Affiliation:

Keywords: Thebaine, morphinandiene, opioid activity, dopamine activity, orvinols

Abstract: The most practical synthetic routes to the preparation of as important pharmaceuticals as oxycodone, naloxone, naltrexone, nalbuphine and buprenorphine have utilized the alkaloid, thebaine, as a starting material. This review intends to focus on chemical transformations of morphinans which resulted in morphinandiene derivatives with well-established and novel pharmacological potencies. These chemical transformations were mainly associated with the formation and substitution of the unique diene structure of the ring C of the morphinan backbone.

Cite this article as:

Berenyi Sandor, Csutoras Csaba and Sipos Attila, Recent Developments in the Chemistry of Thebaine and its Transformation Products as Pharmacological Targets, Current Medicinal Chemistry 2009; 16 (25) . https://dx.doi.org/10.2174/092986709788803295