2-Arylbenzothiazole as a Privileged Scaffold in Drug Discovery

Title: 2-Arylbenzothiazole as a Privileged Scaffold in Drug Discovery

Volume: 16 Issue: 19

Author(s): A. A. Weekes and A. D. Westwell

Affiliation:

Keywords: 2-Arylbenzothiazoles, synthesis, Alzheimer's disease diagnosis, positron emission tomography, antitumour agents

Abstract: Substituted 2-arylbenzothiazoles have emerged in recent years as an important pharmacophore in a number of diagnostic and therapeutic settings. Attractive features of drug candidates based on this benzothiazole scaffold include their synthetic accessibility, and synthetic approaches to 2-arylbenzothiazole-based compounds will be reviewed here. Examples of 2-arylbenzothiazoles endowed with diagnostic/therapeutic activity include the 2-(4-aminophenyl)benzothiazole series, which has a remarkable activity profile in both the potential non-invasive diagnosis of Alzheimers disease and as antitumour agents.

Cite this article as:

Weekes A. A. and Westwell D. A., 2-Arylbenzothiazole as a Privileged Scaffold in Drug Discovery, Current Medicinal Chemistry 2009; 16 (19) . https://dx.doi.org/10.2174/092986709788682137