Purinergic Receptors and Pain

Title: Purinergic Receptors and Pain

Volume: 15 Issue: 15

Author(s): Geoffrey Burnstock

Affiliation:

Keywords: ATP, bladder, gut, inflammatory, joints, mechanosensory transduction, neuropathic

Abstract: There is a brief summary of the early background literature about purinergic signalling and its involvement in pain, of ATP storage, release and ectoenzymatic breakdown and of the current classification of receptor subtypes for purines and pyrimidines. The review then focuses on purinergic mechanosensory transduction involved in visceral, cutaneous and musculoskeletal nociception and on the roles played by P2X3, P2Y2/3, P2X4, P2X7 and P2Y12 receptors in neuropathic and inflammatory pain. Current developments of compounds for the therapeutic treatment of both visceral and neuropathic pain are discussed.

Cite this article as:

Burnstock Geoffrey, Purinergic Receptors and Pain, Current Pharmaceutical Design 2009; 15 (15) . https://dx.doi.org/10.2174/138161209788186335