Identifying Key Clinical Indicators Associated with the Risk of Death in Hospitalized COVID-19 Patients

Title:Identifying Key Clinical Indicators Associated with the Risk of Death in Hospitalized COVID-19 Patients

Volume: 19

Author(s): QingLan Ma, Jingxin Ren, Lei Chen, Wei Guo, KaiYan Feng, Tao Huang*Yu-Dong Cai

Affiliation:

• Bio-Med Big Data Center, CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China
• CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China

Abstract: Background: Accurately predicting survival in hospitalized COVID-19 patients is crucial but challenging due to multiple risk factors. This study addresses the limitations of existing research by proposing a comprehensive machine-learning framework to identify key mortality risk factors and develop a robust predictive model.

Objective: This study proposes an analytical framework that leverages various machine learning techniques to predict the survival of hospitalized COVID-19 patients accurately. The framework comprehensively evaluates multiple clinical indicators and their associations with mortality risk.

Method: Patient data, including gender, age, health condition, and smoking habits, was divided into discharged (n=507) and deceased (n=300) categories. Each patient was characterized by 92 clinical features. The framework incorporated seven feature ranking algorithms (LASSO, LightGBM, MCFS, mRMR, RF, CATBoost, and XGBoost), the IFS method, and four classification algorithms (DT, KNN, RF, and SVM).

Results: Age, diabetes, dyspnea, chronic kidney failure, and high blood pressure were identified as the most important risk factors. The best model achieved an F1-score of 0.857 using KNN with 34 selected features.

Conclusion: Our findings provide a comprehensive analysis of COVID-19 mortality risk factors and develops a robust predictive model. The findings highlight the increased risk in patients with comorbidities, consistent with existing literature. The proposed framework can aid in developing personalized treatment plans and allocating healthcare resources effectively.

Cite this article as:

Ma QingLan, Ren Jingxin, Chen Lei, Guo Wei, Feng KaiYan, Huang Tao*, Cai Yu-Dong, Identifying Key Clinical Indicators Associated with the Risk of Death in Hospitalized COVID-19 Patients, Current Bioinformatics 2024; 19 () . https://dx.doi.org/10.2174/0115748936306893240720192301

DOI https://dx.doi.org/10.2174/0115748936306893240720192301	Print ISSN 1574-8936
Publisher Name Bentham Science Publisher	Online ISSN 2212-392X