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Current Proteomics

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ISSN (Print): 1570-1646
ISSN (Online): 1875-6247

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Mini-Review Article

A Complete Sojourn of Monoclonal Antibodies: AI, Rare Diseases / Disorders And Immunotoxic Effects

In Press, (this is not the final "Version of Record"). Available online 29 July, 2024
Author(s): Sonakshi Garg, Gurisha Garg, Preeti Patel*, Ghanshyam Das Gupta and Balak Das Kurmi*
Published on: 29 July, 2024

DOI: 10.2174/0115701646313765240610062419

Price: $95

Abstract

Monoclonal antibodies (mAbs) are magic bullets proved to be a wonder in the pharmaceutical as well as medical fields. These are produced by various methods like hybridoma technology, phage display technology, YAC technology, and transgenic animals and plants. Based on the percentage of animal origin, mAbs are divided into chimeric, murine, humanized, and fully human. This review covers the history and methods of mAb production, immunotoxicity (Immunosuppression, immunostimulant, autoimmunity, hypersensitivity) associated with mAbs, and targets of mAbs. It also compiles mAb production using AI, new modifications, and novel mAbs, with its various clinical trial information ensuring the use of mAbs in rare diseases and disorders.

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